|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0016 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0 |
0.0064 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0029 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0008 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0093 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.024 |
0.0021 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.1 |
0.13 |
0.24 |
0.15 |
0.13 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0062 |
0.0077 |
0.01 |
0.0042 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0029 |
0.0041 |
0.0017 |
0.013 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0081 |
0.0041 |
0.0026 |
0.0008 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.15 |
0.0041 |
0.0 |
0.0 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0099 |
0.0021 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.007 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0087 |
0.001 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.035 |
0.0021 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.014 |
0.00085 |
0.011 |
0.0033 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.001 |
0.0 |
0.0048 |
0.0042 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0085 |
0.0016 |
0.005 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0041 |
0.0021 |
0.0 |
0.0 |
0.0033 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0087 |
0.22 |
0.099 |
0.21 |
0.29 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0072 |
0.006 |
0.014 |
0.034 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.025 |
0.0072 |
0.0085 |
0.0072 |
0.0084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
T
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.013 |
0.001 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0041 |
0.0017 |
0.0008 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0064 |
0.0067 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.014 |
0.012 |
0.0056 |
0.031 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0043 |
0.0072 |
0.013 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.016 |
0.0041 |
0.0043 |
0.012 |
0.024 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.12 |
0.15 |
0.07 |
0.052 |
0.084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0064 |
0.033 |
0.0 |
0.034 |
0.012 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
G
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0016 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.064 |
0.0082 |
0.0 |
0.008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.033 |
0.041 |
0.044 |
0.07 |
0.026 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.066 |
0.047 |
0.016 |
0.052 |
0.032 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.007 |
0.0082 |
0.0 |
0.016 |
0.0084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
G
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.015 |
0.001 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.012 |
0.0021 |
0.0043 |
0.004 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.01 |
0.016 |
0.0034 |
0.038 |
0.028 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0062 |
0.0026 |
0.012 |
0.005 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.0042 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0093 |
0.014 |
0.046 |
0.029 |
0.034 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
T
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.01 |
0.0041 |
0.0068 |
0.0032 |
0.0042 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0076 |
0.0041 |
0.0 |
0.0016 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.011 |
0.056 |
0.0017 |
0.033 |
0.0084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0047 |
0.0041 |
0.0 |
0.021 |
0.01 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.015 |
0.02 |
0.027 |
0.014 |
0.0075 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0047 |
0.02 |
0.061 |
0.016 |
0.027 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0081 |
0.0041 |
0.051 |
0.0008 |
0.0075 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0041 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.02 |
0.0017 |
0.037 |
0.005 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0035 |
0.0021 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0029 |
0.0 |
0.0034 |
0.0032 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0035 |
0.0021 |
0.0077 |
0.004 |
0.0059 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.013 |
0.001 |
0.065 |
0.0016 |
0.024 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0052 |
0.0072 |
0.015 |
0.0008 |
0.0025 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.001 |
0.0051 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.011 |
0.0017 |
0.0064 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0029 |
0.0021 |
0.0 |
0.0056 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0021 |
0.0051 |
0.0008 |
0.005 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0064 |
0.0 |
0.0094 |
0.0 |
0.0025 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0052 |
0.0021 |
0.015 |
0.0048 |
0.005 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0035 |
0.017 |
0.04 |
0.016 |
0.029 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0052 |
0.0021 |
0.015 |
0.0072 |
0.0075 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.007 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.006 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
T
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0029 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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A
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G
C
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T
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T
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0021 |
0.0 |
0.0024 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0035 |
0.0 |
0.0 |
0.0016 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.001 |
0.0 |
0.0008 |
0.015 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0076 |
0.0 |
0.0017 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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A
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A
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A
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G
C
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T
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.019 |
0.0041 |
0.006 |
0.0008 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.014 |
0.015 |
0.018 |
0.0042 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0077 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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G
C
T
A
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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G
C
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
A
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A
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T
A
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A
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A
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G
C
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T
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T
G
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T
G
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T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.0 |
0.0 |
0.0067 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
A
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T
A
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T
A
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A
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T
G
C
T
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T
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T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0047 |
0.0021 |
0.00085 |
0.0 |
0.0017 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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A
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G
C
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.001 |
0.0051 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0062 |
0.006 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
A
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A
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C
T
A
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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G
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G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0 |
0.0051 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.0042 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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A
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A
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A
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A
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A
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G
C
T
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T
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T
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T
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T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0017 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
A
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A
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A
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G
C
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T
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T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0041 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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T
A
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A
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T
G
C
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T
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T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0031 |
0.0026 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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A
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A
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T
G
C
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0012 |
0.0021 |
0.0017 |
0.0048 |
0.005 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
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G
C
T
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0064 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0035 |
0.0051 |
0.0043 |
0.0024 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0034 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0016 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
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T
G
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G
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T
G
C
T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0017 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
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T
G
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T
G
C
T
G
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T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.00085 |
0.0008 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0 |
0.0 |
0.00084 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0 |
0.0017 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0064 |
0.0 |
0.00085 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0 |
0.0021 |
0.0 |
0.0032 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.00058 |
0.0 |
0.0 |
0.0 |
0.0 |
|
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
A
C
T
G
C
T
A
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
T
G
C
|
0.0023 |
0.0 |
0.0 |
0.0 |
0.0 |